https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Pyrimidyn-Based Dynamin Inhibitors as Novel Cytotoxic Agents https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47111 Wed 14 Dec 2022 10:19:31 AEDT ]]> The sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54007 Thu 25 Jan 2024 13:53:31 AEDT ]]> Pyrimidine-based inhibitors of dynamin I GTPase activity: competitive inhibition at the pleckstrin homology domain https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32119 (CME) = 65.9 ± 7.7 to 3.7 ± 1.1 mM), which makes this series among the more potent inhibitors of dynamin and CME yet reported. In CME and growth inhibition cell-based assays, the data obtained was consistent with dynamin inhibition. CEREP ExpresS profiling identified off-target effects at the cholecystokinin, dopamine D₂, histamine H₁ and H₂, melanocortin, melatonin, muscarinic M₁ and M₃, neurokinin, opioid KOP and serotonin receptors.]]> Thu 03 May 2018 12:18:53 AEST ]]> Development of quinone analogues as dynamin GTPase inhibitors https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20908 Thu 01 Aug 2019 17:22:27 AEST ]]> Azido and diazarinyl analogues of bis-tyrphostin as asymmetrical inhibitors of dynamin GTPase https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8246 Sat 24 Mar 2018 08:40:38 AEDT ]]> Inhibition of dynamin mediated endocytosis by the dynoles-synthesis and functional activity of a family of indoles https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8338 Sat 24 Mar 2018 08:37:03 AEDT ]]> Iminochromene inhibitors of Dynamins I and II GTPase activity and Endocytosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11334 Sat 24 Mar 2018 08:13:29 AEDT ]]> The Pthaladyns: GTP competitive inhibitors of Dynamin I and II GTPase derived from virtual screening https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10254 Sat 24 Mar 2018 08:13:07 AEDT ]]> Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19893 Sat 24 Mar 2018 07:57:02 AEDT ]]> Isolation and identification of unique marker compounds from the Tasmanian poppy Papaver somniferum N: implications for the identification of illicit heroin of Tasmanian origin https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5016 Sat 24 Mar 2018 07:44:09 AEDT ]]> BiCl3-mediated opening of epoxides, a facile route to chlorohydrins or amino alcohols: one reagent, two paths https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:341 Sat 24 Mar 2018 07:42:27 AEDT ]]> Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:3266 Sat 24 Mar 2018 07:21:22 AEDT ]]> 1,8-Naphthalimide derivatives: new leads against dynamin i GTPase activity https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23187 50 of 19.1 ± 0.3 and 18.5 ± 1.7 μM respectively). Compound 29 showed effective inhibition of clathrin-mediated endocytosis (IC50(CME) 66 μM). The results introduce 29 as an optimised GTP-competitive lead Naphthaladyn™ compound for the further development of naphthalimide-based dynI GTPase inhibitors.]]> Sat 24 Mar 2018 07:10:29 AEDT ]]> Prodrugs of the Archetypal Dynamin Inhibitor Bis-T-22 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50565 Fri 28 Jul 2023 11:27:49 AEST ]]>